GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases.
Identifieur interne : 000340 ( Main/Exploration ); précédent : 000339; suivant : 000341GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases.
Auteurs : Wanchang Cui [États-Unis] ; Xianghong Li [États-Unis] ; Lisa Hull [États-Unis] ; Mang Xiao [États-Unis]Source :
- Scientific reports [ 2045-2322 ] ; 2019.
Descripteurs français
- KwdFr :
- Banque de gènes (MeSH), Cryptococcus neoformans (effets des médicaments et des substances chimiques), Cryptococcus neoformans (effets des radiations), Cryptococcus neoformans (génétique), Facteurs de transcription GATA (métabolisme), Fluconazole (pharmacologie), Hydroxy-urée (pharmacologie), Mutation (génétique), Phylogenèse (MeSH), Protéines fongiques (génétique), Protéines fongiques (métabolisme), Radiotolérance (effets des médicaments et des substances chimiques), Radiotolérance (effets des radiations), Radiotolérance (génétique), Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques), Régulation de l'expression des gènes fongiques (effets des radiations), Sirolimus (pharmacologie), Systèmes de transport d'acides aminés (génétique), Systèmes de transport d'acides aminés (métabolisme).
- MESH :
- effets des médicaments et des substances chimiques : Cryptococcus neoformans, Radiotolérance, Régulation de l'expression des gènes fongiques.
- effets des radiations : Cryptococcus neoformans, Radiotolérance, Régulation de l'expression des gènes fongiques.
- génétique : Cryptococcus neoformans, Mutation, Protéines fongiques, Radiotolérance, Systèmes de transport d'acides aminés.
- métabolisme : Facteurs de transcription GATA, Protéines fongiques, Systèmes de transport d'acides aminés.
- pharmacologie : Fluconazole, Hydroxy-urée, Sirolimus.
- Banque de gènes, Phylogenèse.
English descriptors
- KwdEn :
- Amino Acid Transport Systems (genetics), Amino Acid Transport Systems (metabolism), Cryptococcus neoformans (drug effects), Cryptococcus neoformans (genetics), Cryptococcus neoformans (radiation effects), Fluconazole (pharmacology), Fungal Proteins (genetics), Fungal Proteins (metabolism), GATA Transcription Factors (metabolism), Gene Expression Regulation, Fungal (drug effects), Gene Expression Regulation, Fungal (radiation effects), Gene Library (MeSH), Hydroxyurea (pharmacology), Mutation (genetics), Phylogeny (MeSH), Radiation Tolerance (drug effects), Radiation Tolerance (genetics), Radiation Tolerance (radiation effects), Sirolimus (pharmacology).
- MESH :
- chemical , genetics : Amino Acid Transport Systems, Fungal Proteins.
- chemical , metabolism : Amino Acid Transport Systems, Fungal Proteins, GATA Transcription Factors.
- drug effects : Cryptococcus neoformans, Gene Expression Regulation, Fungal, Radiation Tolerance.
- genetics : Cryptococcus neoformans, Mutation, Radiation Tolerance.
- chemical , pharmacology : Fluconazole, Hydroxyurea, Sirolimus.
- radiation effects : Cryptococcus neoformans, Gene Expression Regulation, Fungal, Radiation Tolerance.
- Gene Library, Phylogeny.
Abstract
Cryptococcus neoformans is a basidiomycete fungus that is highly resistant to ionizing radiation and has been identified in highly radioactive environments. Transcription factors (TFs) are master regulators of gene expression by binding to specific DNA sequences within promoters of target genes. A library of 322 signature-tagged gene deletion strains for 155 C. neoformans TF genes has been established. Previous phenome-based functional analysis of the C. neoformans TF mutant library identified key TFs important for various phenotypes, such as growth, differentiation, virulence-factor production, and stress responses. Here, utilizing the established TF mutant library, we identified 5 TFs that are important for radiation sensitivity, including SRE1, BZP2, GAT5, GAT6, and HCM1. Interestingly, BZP2, GAT5 and GAT6 all belong to the GATA-type transcription factors. These factors regulate transcription of nitrogen catabolite repression (NCR) sensitive genes when preferred nitrogen sources are absent or limiting. In addition to radiation, we found that specific GATA factors are important for other stressors such as rapamycin, fluconazole, and hydroxyurea treatment. Using real-time PCR method, we studied the expression of GATA down-stream genes after radiation exposure and identified that AAP4, AAP5 and URO1 were differentially expressed in the GAT5 and GAT6 mutants compared to the wild type cells. In summary, our data suggest that GATA TFs are important for radiation sensitivity in C. neoformans by regulating specific downstream AAP genes.
DOI: 10.1038/s41598-019-42778-7
PubMed: 31015536
PubMed Central: PMC6478845
Affiliations:
Links toward previous steps (curation, corpus...)
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Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Li, Xianghong" sort="Li, Xianghong" uniqKey="Li X" first="Xianghong" last="Li">Xianghong Li</name><affiliation wicri:level="2"><nlm:affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hull, Lisa" sort="Hull, Lisa" uniqKey="Hull L" first="Lisa" last="Hull">Lisa Hull</name><affiliation wicri:level="2"><nlm:affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Xiao, Mang" sort="Xiao, Mang" uniqKey="Xiao M" first="Mang" last="Xiao">Mang Xiao</name><affiliation wicri:level="2"><nlm:affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. mang.xiao@usuhs.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Transport Systems (genetics)</term><term>Amino Acid Transport Systems (metabolism)</term><term>Cryptococcus neoformans (drug effects)</term><term>Cryptococcus neoformans (genetics)</term><term>Cryptococcus neoformans (radiation effects)</term><term>Fluconazole (pharmacology)</term><term>Fungal Proteins (genetics)</term><term>Fungal Proteins (metabolism)</term><term>GATA Transcription Factors (metabolism)</term><term>Gene Expression Regulation, Fungal (drug effects)</term><term>Gene Expression Regulation, Fungal (radiation effects)</term><term>Gene Library (MeSH)</term><term>Hydroxyurea (pharmacology)</term><term>Mutation (genetics)</term><term>Phylogeny (MeSH)</term><term>Radiation Tolerance (drug effects)</term><term>Radiation Tolerance (genetics)</term><term>Radiation Tolerance (radiation effects)</term><term>Sirolimus (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Banque de gènes (MeSH)</term><term>Cryptococcus neoformans (effets des médicaments et des substances chimiques)</term><term>Cryptococcus neoformans (effets des radiations)</term><term>Cryptococcus neoformans (génétique)</term><term>Facteurs de transcription GATA (métabolisme)</term><term>Fluconazole (pharmacologie)</term><term>Hydroxy-urée (pharmacologie)</term><term>Mutation (génétique)</term><term>Phylogenèse (MeSH)</term><term>Protéines fongiques (génétique)</term><term>Protéines fongiques (métabolisme)</term><term>Radiotolérance (effets des médicaments et des substances chimiques)</term><term>Radiotolérance (effets des radiations)</term><term>Radiotolérance (génétique)</term><term>Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques)</term><term>Régulation de l'expression des gènes fongiques (effets des radiations)</term><term>Sirolimus (pharmacologie)</term><term>Systèmes de transport d'acides aminés (génétique)</term><term>Systèmes de transport d'acides aminés (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Amino Acid Transport Systems</term><term>Fungal Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acid Transport Systems</term><term>Fungal Proteins</term><term>GATA Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cryptococcus neoformans</term><term>Gene Expression Regulation, Fungal</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cryptococcus neoformans</term><term>Radiotolérance</term><term>Régulation de l'expression des gènes fongiques</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Cryptococcus neoformans</term><term>Radiotolérance</term><term>Régulation de l'expression des gènes fongiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cryptococcus neoformans</term><term>Mutation</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cryptococcus neoformans</term><term>Mutation</term><term>Protéines fongiques</term><term>Radiotolérance</term><term>Systèmes de transport d'acides aminés</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription GATA</term><term>Protéines fongiques</term><term>Systèmes de transport d'acides aminés</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fluconazole</term><term>Hydroxy-urée</term><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fluconazole</term><term>Hydroxyurea</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cryptococcus neoformans</term><term>Gene Expression Regulation, Fungal</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Library</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Banque de gènes</term><term>Phylogenèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cryptococcus neoformans is a basidiomycete fungus that is highly resistant to ionizing radiation and has been identified in highly radioactive environments. Transcription factors (TFs) are master regulators of gene expression by binding to specific DNA sequences within promoters of target genes. A library of 322 signature-tagged gene deletion strains for 155 C. neoformans TF genes has been established. Previous phenome-based functional analysis of the C. neoformans TF mutant library identified key TFs important for various phenotypes, such as growth, differentiation, virulence-factor production, and stress responses. Here, utilizing the established TF mutant library, we identified 5 TFs that are important for radiation sensitivity, including SRE1, BZP2, GAT5, GAT6, and HCM1. Interestingly, BZP2, GAT5 and GAT6 all belong to the GATA-type transcription factors. These factors regulate transcription of nitrogen catabolite repression (NCR) sensitive genes when preferred nitrogen sources are absent or limiting. In addition to radiation, we found that specific GATA factors are important for other stressors such as rapamycin, fluconazole, and hydroxyurea treatment. Using real-time PCR method, we studied the expression of GATA down-stream genes after radiation exposure and identified that AAP4, AAP5 and URO1 were differentially expressed in the GAT5 and GAT6 mutants compared to the wild type cells. In summary, our data suggest that GATA TFs are important for radiation sensitivity in C. neoformans by regulating specific downstream AAP genes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31015536</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>07</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>04</Month><Day>23</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases.</ArticleTitle><Pagination><MedlinePgn>6385</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-019-42778-7</ELocationID><Abstract><AbstractText>Cryptococcus neoformans is a basidiomycete fungus that is highly resistant to ionizing radiation and has been identified in highly radioactive environments. Transcription factors (TFs) are master regulators of gene expression by binding to specific DNA sequences within promoters of target genes. A library of 322 signature-tagged gene deletion strains for 155 C. neoformans TF genes has been established. Previous phenome-based functional analysis of the C. neoformans TF mutant library identified key TFs important for various phenotypes, such as growth, differentiation, virulence-factor production, and stress responses. Here, utilizing the established TF mutant library, we identified 5 TFs that are important for radiation sensitivity, including SRE1, BZP2, GAT5, GAT6, and HCM1. Interestingly, BZP2, GAT5 and GAT6 all belong to the GATA-type transcription factors. These factors regulate transcription of nitrogen catabolite repression (NCR) sensitive genes when preferred nitrogen sources are absent or limiting. In addition to radiation, we found that specific GATA factors are important for other stressors such as rapamycin, fluconazole, and hydroxyurea treatment. Using real-time PCR method, we studied the expression of GATA down-stream genes after radiation exposure and identified that AAP4, AAP5 and URO1 were differentially expressed in the GAT5 and GAT6 mutants compared to the wild type cells. In summary, our data suggest that GATA TFs are important for radiation sensitivity in C. neoformans by regulating specific downstream AAP genes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Wanchang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>XiangHong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hull</LastName><ForeName>Lisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Mang</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8743-3882</Identifier><AffiliationInfo><Affiliation>Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. mang.xiao@usuhs.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026905">Amino Acid Transport Systems</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050980">GATA Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>8VZV102JFY</RegistryNumber><NameOfSubstance UI="D015725">Fluconazole</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical><Chemical><RegistryNumber>X6Q56QN5QC</RegistryNumber><NameOfSubstance UI="D006918">Hydroxyurea</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D026905" MajorTopicYN="N">Amino Acid Transport Systems</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003455" MajorTopicYN="N">Cryptococcus neoformans</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015725" MajorTopicYN="N">Fluconazole</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050980" MajorTopicYN="N">GATA Transcription Factors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015723" MajorTopicYN="N">Gene Library</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006918" MajorTopicYN="N">Hydroxyurea</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011836" MajorTopicYN="N">Radiation Tolerance</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31015536</ArticleId><ArticleId IdType="doi">10.1038/s41598-019-42778-7</ArticleId><ArticleId IdType="pii">10.1038/s41598-019-42778-7</ArticleId><ArticleId IdType="pmc">PMC6478845</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Cui, Wanchang" sort="Cui, Wanchang" uniqKey="Cui W" first="Wanchang" last="Cui">Wanchang Cui</name></region><name sortKey="Hull, Lisa" sort="Hull, Lisa" uniqKey="Hull L" first="Lisa" last="Hull">Lisa Hull</name><name sortKey="Li, Xianghong" sort="Li, Xianghong" uniqKey="Li X" first="Xianghong" last="Li">Xianghong Li</name><name sortKey="Xiao, Mang" sort="Xiao, Mang" uniqKey="Xiao M" 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